Histone H2A.Z

H2AZ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F66, 3WA9, 4CAY, 4NFT, 5FUG, 5CHL
Identifiers
Aliases	H2AZ1, H2A.Z-1, H2A.z, H2A/z, H2AZ, H2A histone family member Z, H2A.Z variant histone 1, H2AFZ
External IDs	OMIM: 142763; MGI: 1888388; HomoloGene: 80218; GeneCards: H2AZ1; OMA:H2AZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	99,950,355 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	137,572,683 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; gingival epithelium; ; palpebral conjunctiva; ; germinal epithelium; ; trabecular bone; ; human penis; ; epithelium of nasopharynx; ; mucosa of transverse colon;
	Top expressed in
	ventricular zone; ; tail of embryo; ; blastocyst; ; embryo; ; genital tubercle; ; thymus; ; embryo; ; spermatocyte; ; epiblast; ; neural tube;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleosomal DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; chromatin DNA binding; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; protein heterodimerization activity;
Cellular component	nucleosome; extracellular exosome; Barr body; nucleus; chromosome;
Biological process	cellular response to estradiol stimulus; positive regulation of transcription by RNA polymerase II; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	3015
	51788
	ENSG00000164032
	ENSMUSG00000037894
	P0C0S5
	P0C0S6
	NM_002106
	NM_016750; NM_001316995
	NP_002097
	NP_001303924; NP_058030
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A.Z is a protein that in humans is encoded by the H2AFZ gene.^[5]^[6]

Template:PBB Summary

Recent evidence also points to a role for H2A.Z in repressing a subset of ncRNAs, derepressing CUTs, as well as mediation higher order chromatin structure formation.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164032 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037894 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hatch CL, Bonner WM (Oct 1990). "The human histone H2A.Z gene. Sequence and regulation". J Biol Chem. 265 (25): 15211–8. PMID 1697587.
^ "Entrez Gene: H2AFZ H2A histone family, member Z".
^ Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner,Nir Friedman,Sandra Clauder-Mu€nster, Lars M. Steinmetz, Oliver J. Rando,Laurie A. Boyer, and Craig L. Peterson. (2015) Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis doi:10.1016/j.celrep.2015.10.030

References

Further reading