HABP2

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HABP2
Identifiers
Aliases HABP2, FSAP, HABP, HGFAL, PHBP, NMTC5, hyaluronan binding protein 2
External IDs MGI: 1196378 HomoloGene: 3050 GeneCards: HABP2
RNA expression pattern
PBB GE HABP2 206010 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004132
NM_001177660

NM_146101
NM_001329935
NM_001329936

RefSeq (protein)

NP_001171131
NP_004123

NP_666213.1
NP_001316864
NP_001316865
NP_666213

Location (UCSC) Chr 10: 113.55 – 113.59 Mb Chr 19: 56.29 – 56.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.[3][4][5]

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M (Dec 1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem. 119 (6): 1157–65. doi:10.1093/oxfordjournals.jbchem.a021362. PMID 8827452. 
  4. ^ Romisch J (Nov 2002). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol Chem. 383 (7–8): 1119–24. doi:10.1515/BC.2002.121. PMID 12437095. 
  5. ^ a b "Entrez Gene: HABP2 hyaluronan binding protein 2". 

Further reading[edit]