HAT1

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HAT1
PDB 2p0w EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HAT1, KAT1, histone acetyltransferase 1
External IDs MGI: 96013 HomoloGene: 2701 GeneCards: HAT1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033085
NM_003642

NM_026115

RefSeq (protein)

NP_003633

NP_080391.2
NP_080391

Location (UCSC) Chr 2: 171.92 – 171.98 Mb Chr 2: 71.39 – 71.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene.[3][4]

Function[edit]

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998). "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.". Curr. Biol. 8 (2): 96–108. doi:10.1016/S0960-9822(98)70040-5. PMID 9427644. 
  4. ^ a b "Entrez Gene: histone acetyltransferase 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.