HERPUD1

HERPUD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGD
Identifiers
Aliases	HERPUD1, HERP, Mif1, SUP, homocysteine inducible ER protein with ubiquitin like domain 1
External IDs	OMIM: 608070; MGI: 1927406; HomoloGene: 40973; GeneCards: HERPUD1; OMA:HERPUD1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,944,864 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,122,005 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; tonsil; ; trachea; ; tibia; ; parietal pleura; ; rectum; ; olfactory bulb; ; pylorus;
	Top expressed in
	lacrimal gland; ; parotid gland; ; right kidney; ; seminal vesicula; ; submandibular gland; ; left lobe of liver; ; islet of Langerhans; ; pyloric antrum; ; calvaria; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; protein binding; molecular function; ubiquitin ligase-substrate adaptor activity;
Cellular component	integral component of membrane; Lewy body core; calcium channel complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of intrinsic apoptotic signaling pathway; regulation of protein ubiquitination; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cellular calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; regulation of ER-associated ubiquitin-dependent protein catabolic process; response to unfolded protein; retrograde protein transport, ER to cytosol; positive regulation of protein binding; endoplasmic reticulum unfolded protein response; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9709
	64209
	ENSG00000051108
	ENSMUSG00000031770
	Q15011
	Q9JJK5
	NM_001010989; NM_001010990; NM_001272103; NM_014685
	NM_022331; NM_001357205
	NP_001010989; NP_001259032; NP_055500; NP_001259032.1
	NP_071726; NP_001344134
	Wikidata
View/Edit Human	View/Edit Mouse

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

HERPUD1 has been shown to interact with UBQLN1^[8] and UBQLN2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000051108 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kokame K, Agarwala KL, Kato H, Miyata T (Nov 2000). "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress". J Biol Chem. 275 (42): 32846–53. doi:10.1074/jbc.M002063200. PMID 10922362.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ, Terleth C (Apr 2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ ^a ^b Kim, Tae-Yeon; Kim Eunmin; Yoon Sungjoo Kim; Yoon Jong-Bok (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochem. Biophys. Res. Commun. 369 (2). United States: 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Interactions

References

Further reading