HEXIM2

HEXIM2
Identifiers
Aliases	HEXIM2, L3, hexamethylene bisacetamide inducible 2, HEXIM P-TEFb complex subunit 2
External IDs	OMIM: 615695; MGI: 1918309; HomoloGene: 16946; GeneCards: HEXIM2; OMA:HEXIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,170,040 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,030,702 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left testis; ; right testis; ; testicle; ; muscle of thigh; ; gonad; ; pancreatic ductal cell; ; right uterine tube; ; sural nerve; ; apex of heart;
	Top expressed in
	primary oocyte; ; zygote; ; spermatid; ; spermatocyte; ; secondary oocyte; ; neural layer of retina; ; Rostral migratory stream; ; substantia nigra; ; seminiferous tubule; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase inhibitor activity; snRNA binding; protein binding; 7SK snRNA binding; identical protein binding;
Cellular component	nucleoplasm; cytoplasm; cytosol; nuclear speck; nucleus;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	124790
	71059
	ENSG00000168517
	ENSMUSG00000043372
	Q96MH2
	Q3TVI4
NM_001303436; NM_001303437; NM_001303438; NM_001303439; NM_001303440;
	NM_001303441; NM_001303442; NM_001303443; NM_001303444; NM_144608
	NM_001130515; NM_001130516; NM_027658
NP_001290365; NP_001290366; NP_001290367; NP_001290368; NP_001290369;
	NP_001290370; NP_001290371; NP_001290372; NP_001290373; NP_653209
	NP_001123987; NP_001123988; NP_081934
	Wikidata
View/Edit Human	View/Edit Mouse

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.^[5]^[6] Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168517 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043372 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
^ "Entrez Gene: HEXIM2 hexamthylene bis-acetamide inducible 2".

References

Further reading