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Protein HINT1 PDB 1av5.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1
External IDs MGI: 1321133 HomoloGene: 3904 GeneCards: HINT1
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for HINT1
Genomic location for HINT1
Band 5q23.3 Start 131,159,027 bp[1]
End 131,171,735 bp[1]
RNA expression pattern
PBB GE HINT1 208826 x at fs.png

PBB GE HINT1 207721 x at fs.png

PBB GE HINT1 200093 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 131.16 – 131.17 Mb Chr 5: 54.87 – 54.87 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene.[5][6] It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.[7][8] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.[8][9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169567 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020267 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF (Feb 1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)". Genomics. 36 (1): 151–6. doi:10.1006/geno.1996.0435. PMID 8812426. 
  6. ^ "Entrez Gene: HINT1 histidine triad nucleotide binding protein 1". 
  7. ^ Wang L, Li H, Zhang Y, Santella RM, Weinstein IB (Apr 2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int J Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231Freely accessible. PMID 19089909. 
  8. ^ a b Lee YN, Nechushtan H, Figov N, Razin E (Feb 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237. 
  9. ^ Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (June 2009). "LysRS serves as a key signaling molecule in the immune response by regulating gene expression". Mol Cell. 34 (5): 603–11. doi:10.1016/j.molcel.2009.05.019. PMID 19524539. 

Further reading[edit]