HIPK1

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HIPK1
Identifiers
Aliases HIPK1, Myak, Nbak2, homeodomain interacting protein kinase 1
External IDs MGI: 1314873 HomoloGene: 56483 GeneCards: HIPK1
Targeted by Drug
staurosporine[1]
RNA expression pattern
PBB GE HIPK1 212291 at fs.png

PBB GE HIPK1 212293 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152696
NM_181358
NM_198268
NM_198269

NM_001301304
NM_001301306
NM_010432

RefSeq (protein)

NP_689909
NP_852003
NP_938009
NP_938010

Location (UCSC) Chr 1: 113.93 – 113.98 Mb Chr 3: 103.74 – 103.79 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.[4]

Function[edit]

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.[4]

Interactions[edit]

HIPK1 has been shown to interact with P53.[5]

References[edit]

  1. ^ "Drugs that physically interact with Homeodomain interacting protein kinase 1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1". 
  5. ^ Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5431–6. doi:10.1073/pnas.0530308100. PMC 154362Freely accessible. PMID 12702766. 

Further reading[edit]