Jump to content

HIPK1

From Wikipedia, the free encyclopedia
HIPK1
Identifiers
AliasesHIPK1, Myak, Nbak2, homeodomain interacting protein kinase 1
External IDsOMIM: 608003; MGI: 1314873; HomoloGene: 56483; GeneCards: HIPK1; OMA:HIPK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301304
NM_001301306
NM_010432

RefSeq (protein)

NP_001288233
NP_001288235
NP_034562

Location (UCSC)Chr 1: 113.93 – 113.98 MbChr 3: 103.65 – 103.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans is encoded by the HIPK1 gene.[5]

Function

[edit]

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.[5]

Interactions

[edit]

HIPK1 has been shown to interact with P53.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163349Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008730Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1".
  6. ^ Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5431–6. Bibcode:2003PNAS..100.5431K. doi:10.1073/pnas.0530308100. PMC 154362. PMID 12702766.

Further reading

[edit]