HIST1H2AG

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HIST1H2AG
Protein HIST1H2AG PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST1H2AG, H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f, histone cluster 1, H2ag, histone cluster 1 H2A family member g
External IDs MGI: 2448300 HomoloGene: 137349 GeneCards: HIST1H2AG
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIST1H2AG
Genomic location for HIST1H2AG
Band 6p22.1 Start 27,133,042 bp[1]
End 27,135,291 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021064

NM_178184

RefSeq (protein)

NP_003501
NP_066408
NP_003500
NP_003505
NP_003502

Location (UCSC) Chr 6: 27.13 – 27.14 Mb Chr 6: 21.79 – 21.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AG gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196787 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069309 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821. 
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  7. ^ a b "Entrez Gene: HIST1H2AG histone cluster 1, H2ag". 

Further reading[edit]