HIST1H4A

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HIST1H4A
Protein HIST1H4A PDB 1aoi.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HIST1H4A, H4FA, histone cluster 1, H4a
External IDs MGI: 2448423 HomoloGene: 134481 GeneCards: 8359
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003538

NM_175654

RefSeq (protein)

n/a

Location (UCSC) Chr 6: 26.02 – 26.02 Mb Chr 13: 23.58 – 23.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST1H4A gene.[1][2][3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References[edit]

  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H4A histone cluster 1, H4a". 

Further reading[edit]