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Protein HIST2H2BE PDB 1aoi.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases HIST2H2BE, GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, histone cluster 2, H2be, histone cluster 2 H2B family member e
External IDs HomoloGene: 128426 GeneCards: HIST2H2BE
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HIST2H2BE
Genomic location for HIST2H2BE
Band 1q21.2 Start 149,884,459 bp[1]
End 149,886,652 bp[1]
RNA expression pattern
PBB GE HIST2H2BE 202708 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 149.88 – 149.89 Mb n/a
PubMed search [2] n/a
View/Edit Human

Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene.[3][4][5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184678 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem. 50 (4): 374–85. doi:10.1002/jcb.240500406. PMID 1469070. 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ a b "Entrez Gene: HIST2H2BE histone cluster 2, H2be". 

Further reading[edit]