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Protein HIST2H3C PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HIST2H3C, H3, H3.2, H3/M, H3F2, H3FM, H3FN, histone cluster 2, H3c, histone cluster 2 H3 family member c
External IDs MGI: 3650546 HomoloGene: 134475 GeneCards: HIST2H3C
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HIST2H3C
Genomic location for HIST2H3C
Band 1q21.2 Start 149,839,538 bp[1]
End 149,841,193 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 149.84 – 149.84 Mb n/a
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.[4][5][6]


Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[6]


HIST2H3C has been shown to interact with NCOA6.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203811 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  5. ^ Marashi F, Helms S, Shiels A, Silverstein S, Greenspan DS, Stein G, Stein J (Jul 1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences". Biochem Cell Biol. 64 (4): 277–289. doi:10.1139/o86-039. PMID 3013246. 
  6. ^ a b "Entrez Gene: HIST2H3C histone cluster 2, H3c". 
  7. ^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. 23 (1): 140–149. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670Freely accessible. PMID 12482968. 

Further reading[edit]