HIST4H4

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HIST4H4
Protein HIST4H4 PDB 1aoi.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HIST4H4, H4/p, histone cluster 4, H4
External IDs MGI: 2448432 HomoloGene: 134468 GeneCards: HIST4H4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175054

NM_175656

RefSeq (protein)
Location (UCSC) Chr 12: 14.77 – 14.77 Mb Chr 13: 22.04 – 22.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.[3]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  4. ^ "Entrez Gene: HIST4H4 histone cluster 4, H4". 

Further reading[edit]