HIST4H4

H4-16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4-16, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
External IDs	OMIM: 615069; MGI: 2448432; HomoloGene: 134468; GeneCards: H4-16; OMA:H4-16 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	14,771,131 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,225,532 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; Achilles tendon; ; epithelium of colon; ; tonsil; ; right uterine tube; ; prostate; ; testicle; ; sural nerve; ; body of pancreas; ; stomach;
	Top expressed in
	muscle of thigh; ; granulocyte; ; blood; ; triceps brachii muscle; ; ventricular zone; ; sternocleidomastoid muscle; ; temporal muscle; ; quadriceps femoris muscle; ; soleus muscle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; protein binding; protein heterodimerization activity; DNA binding; histone binding; RNA binding;
Cellular component	membrane; chromosome; nucleoplasm; extracellular region; nuclear chromosome; nucleosome; extracellular exosome; nucleus; extracellular matrix; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; protein heterotetramerization; negative regulation of megakaryocyte differentiation; CENP-A containing chromatin assembly; DNA replication-dependent chromatin assembly; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; DNA-templated transcription, initiation; double-strand break repair via nonhomologous end joining; beta-catenin-TCF complex assembly; telomere capping; nucleosome assembly; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	121504
	319158
	ENSG00000197837
	ENSMUSG00000060639
	P62805
	P62806
	NM_175054
	NM_175656
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197837 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060639 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

References

Further reading