HNRPH2

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HNRNPH2
Protein HNRPH2 PDB 1wez.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HNRNPH2, FTP3, HNRPH', HNRPH2, hnRNPH', heterogeneous nuclear ribonucleoprotein H2 (H')
External IDs MGI: 1201779 HomoloGene: 23165 GeneCards: 3188
RNA expression pattern
PBB GE HNRPH2 201132 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019597
NM_001032393

NM_019868
NM_001313716
NM_001313717

RefSeq (protein)

NP_001027565.1
NP_062543.1

NP_001300645.1
NP_001300646.1
NP_063921.1

Location (UCSC) Chr X: 101.41 – 101.41 Mb Chr X: 134.6 – 134.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.[1][2]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabry disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.[2]

References[edit]

  1. ^ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401. 
  2. ^ a b "Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H')". 

Further reading[edit]