HSD17B14

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HSD17B14
5l7y.jpg
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHSD17B14, DHRS10, SDR47C1, retSDR3, hydroxysteroid (17-beta) dehydrogenase 14, hydroxysteroid 17-beta dehydrogenase 14
External IDsMGI: 1913315 HomoloGene: 133800 GeneCards: HSD17B14
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HSD17B14
Genomic location for HSD17B14
Band19q13.33Start48,813,017 bp[1]
End48,836,678 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016246

NM_025330

RefSeq (protein)

NP_057330

n/a

Location (UCSC)Chr 19: 48.81 – 48.84 MbChr 7: 45.55 – 45.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.[5][6]

17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087076 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030825 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Zhu Y, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S. Hormones, Brain and Behavior. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.
  6. ^ Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9.
  7. ^ Sivik T, Vikingsson S, Gréen H, Jansson A (2012). "Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 44 (13): 949–56. doi:10.1055/s-0032-1321815. PMID 22864907.