Hermeskeil is a town in the Trier-Saarburg district, in Rhineland-Palatinate, Germany. It is situated in the Hunsrück, approx. 25 km southeast of Trier. Its population is about 5,900.
Hermeskeil is the seat of the Verbandsgemeinde ("collective municipality") Hermeskeil.
The old locomotive depot, Bahnbetriebswerk Hermeskeil is now a museum housing German steam engines.
The Flugausstellung aircraft museum displays more than 100 aircraft and is the largest private museum of that kind in Europe.
A Gaulish burial of the 1st century AD was discovered in a field near Hermeskeil in 2009.