IARS

IARS1
Identifiers
Aliases	IARS1, isoleucyl-tRNA synthetase 1, ILERS, isoleucyl-tRNA synthetase, PRO0785, GRIDHH, IRS, ILRS, IARS
External IDs	OMIM: 600709; MGI: 2145219; HomoloGene: 5325; GeneCards: IARS1; OMA:IARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	92,293,756 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,887,743 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; corpus epididymis; ; middle temporal gyrus; ; tail of epididymis; ; Skeletal muscle tissue of biceps brachii; ; caput epididymis; ; right ventricle; ; oral cavity; ; glutes; ; trabecular bone;
	Top expressed in
	primary oocyte; ; motor neuron; ; secondary oocyte; ; primitive streak; ; tail of embryo; ; migratory enteric neural crest cell; ; lacrimal gland; ; seminal vesicula; ; somite; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; GTPase binding; ATP binding; aminoacyl-tRNA editing activity; tRNA binding; isoleucine-tRNA ligase activity;
Cellular component	membrane; extracellular exosome; cytoplasm; aminoacyl-tRNA synthetase multienzyme complex; cytosol;
Biological process	protein biosynthesis; tRNA aminoacylation for protein translation; osteoblast differentiation; regulation of translational fidelity; isoleucyl-tRNA aminoacylation; aminoacyl-tRNA metabolism involved in translational fidelity;
	Sources:Amigo / QuickGO
Orthologs
	3376
	105148
	ENSG00000196305
	ENSMUSG00000037851
	P41252; Q6P0M4
	Q8BU30
	NM_002161; NM_013417; NM_001374299; NM_001374300; NM_001374301
	NM_172015
NP_002152; NP_038203; NP_001361228; NP_001361229; NP_001361230;
	NP_001365498; NP_001365500; NP_001365501; NP_001365502; NP_001365503; NP_001365504; NP_001365505; NP_001365506; NP_001365507; NP_001365508; NP_001365509; NP_001365511; NP_001365512; NP_001365513; NP_001365514; NP_001365515; NP_002152.2
	NP_742012
	Wikidata
View/Edit Human	View/Edit Mouse

Isoleucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the IARS gene.^[5]^[6]

Template:PBB Summary

Interactions

IARS has been shown to interact with EPRS.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037851 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nichols RC, Blinder J, Pai SI, Ge Q, Targoff IN, Plotz PH, Liu P (February 1997). "Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24". Genomics. 36 (1): 210–3. doi:10.1006/geno.1996.0449. PMID 8812440.
^ "Entrez Gene: IARS isoleucyl-tRNA synthetase".
^ Rho, S B; Lee J S; Jeong E J; Kim K S; Kim Y G; Kim S (May 1998). "A multifunctional repeated motif is present in human bifunctional tRNA synthetase". J. Biol. Chem. 273 (18). UNITED STATES: 11267–73. doi:10.1074/jbc.273.18.11267. ISSN 0021-9258. PMID 9556618. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading