ING5

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ING5
Protein ING5 PDB 1wen.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ING5, p28inhibitor of growth family member 5
External IDs MGI: 1922816 HomoloGene: 90955 GeneCards: ING5
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032329
NM_001330161
NM_001330162

NM_025454

RefSeq (protein)

NP_001317090
NP_001317091
NP_115705

NP_079730.1
NP_079730

Location (UCSC) Chr 2: 241.69 – 241.73 Mb Chr 1: 93.8 – 93.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.[3][4]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[4]

Interactions[edit]

ING5 has been shown to interact with EP300[3] and P53.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID 12750254. 
  4. ^ a b "Entrez Gene: ING5 inhibitor of growth family, member 5". 

Further reading[edit]