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INPP5D

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Template:PBB Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene.[1][2][3] INPP5D also called SHIP1 was also shown to be a negative regulator of BCR signalling in B cells.[4]

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Interactions

INPP5D has been shown to interact with DOK2,[5] LYN,[6] CD22,[7] Grb2,[8] CRKL,[9] CD31,[10] DOK1[5][11] and SHC1.[1][5][12][13][14]

References

  1. ^ a b Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G (July 1996). "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase". Proc Natl Acad Sci U S A. 93 (4): 1689–93. doi:10.1073/pnas.93.4.1689. PMC 40003. PMID 8643691.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Ware MD, Rosten P, Damen JE, Liu L, Humphries RK, Krystal G (December 1996). "Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation". Blood. 88 (8): 2833–40. PMID 8874179.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: INPP5D inositol polyphosphate-5-phosphatase, 145kDa".
  4. ^ . PMID 24914134. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. ^ a b c Dunant, N M; Wisniewski D; Strife A; Clarkson B; Resh M D (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5). ENGLAND: 317–26. doi:10.1016/S0898-6568(00)00073-5. ISSN 0898-6568. PMID 10822173. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  6. ^ Baran, Christopher P; Tridandapani Susheela; Helgason Cheryl D; Humphries R Keith; Krystal Gerald; Marsh Clay B (October 2003). "The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity". J. Biol. Chem. 278 (40). United States: 38628–36. doi:10.1074/jbc.M305021200. ISSN 0021-9258. PMID 12882960. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  7. ^ Poe, J C; Fujimoto M; Jansen P J; Miller A S; Tedder T F (June 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". J. Biol. Chem. 275 (23). UNITED STATES: 17420–7. doi:10.1074/jbc.M001892200. ISSN 0021-9258. PMID 10748054. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  8. ^ Kavanaugh, W M; Pot D A; Chin S M; Deuter-Reinhard M; Jefferson A B; Norris F A; Masiarz F R; Cousens L S; Majerus P W; Williams L T (April 1996). "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2". Curr. Biol. 6 (4). ENGLAND: 438–45. doi:10.1016/S0960-9822(02)00511-0. ISSN 0960-9822. PMID 8723348. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  9. ^ Arai, A; Kanda E; Nosaka Y; Miyasaka N; Miura O (August 2001). "CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling". J. Biol. Chem. 276 (35). United States: 33282–90. doi:10.1074/jbc.M102924200. ISSN 0021-9258. PMID 11443118. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  10. ^ Pumphrey, N J; Taylor V; Freeman S; Douglas M R; Bradfield P F; Young S P; Lord J M; Wakelam M J; Bird I N; Salmon M; Buckley C D (April 1999). "Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31". FEBS Lett. 450 (1–2). NETHERLANDS: 77–83. doi:10.1016/S0014-5793(99)00446-9. ISSN 0014-5793. PMID 10350061. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  11. ^ van Dijk, T B; van Den Akker E; Amelsvoort M P; Mano H; Löwenberg B; von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10). UNITED STATES: 3406–13. ISSN 0006-4971. PMID 11071635. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  12. ^ Wisniewski, D; Strife A; Swendeman S; Erdjument-Bromage H; Geromanos S; Kavanaugh W M; Tempst P; Clarkson B (April 1999). "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells". Blood. 93 (8). UNITED STATES: 2707–20. ISSN 0006-4971. PMID 10194451. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  13. ^ Leitges, Michael; Gimborn Kerstin; Elis Winfried; Kalesnikoff Janet; Hughes Michael R; Krystal Gerald; Huber Michael (June 2002). "Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation". Mol. Cell. Biol. 22 (12). United States: 3970–80. doi:10.1128/MCB.22.12.3970-3980.2002. ISSN 0270-7306. PMC 133855. PMID 12024011. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  14. ^ March, M E; Lucas D M; Aman M J; Ravichandran K S (September 2000). "p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells". J. Biol. Chem. 275 (39). UNITED STATES: 29960–7. doi:10.1074/jbc.M003714200. ISSN 0021-9258. PMID 10900203. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Further reading

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