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INTS1

From Wikipedia, the free encyclopedia
INTS1
Identifiers
AliasesINTS1, INT1, NET28, integrator complex subunit 1, NDCAGF
External IDsOMIM: 611345; MGI: 1915760; HomoloGene: 53111; GeneCards: INTS1; OMA:INTS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080453

NM_026748

RefSeq (protein)

NP_001073922

NP_081024

Location (UCSC)Chr 7: 1.47 – 1.5 MbChr 5: 139.74 – 139.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. [5]

Function

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INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164880Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029547Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Integrator complex subunit 1". Retrieved 2016-06-11.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.