Intraepithelial neoplasia

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Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an epithelium. The exact dividing line between dysplasia and neoplasia has been very difficult to draw throughout the era of medical science. It varies between persons. In the localizations shown below, the term intraepithelial neoplasia is used to describe more accurately what was historically referred to as epithelial dysplasia. IEN is not cancer, but it is associated with higher risk for developing cancer in future. It is thus sometimes a precancerous condition.


Localization Usual acronym
anal intraepithelial neoplasia AIN
biliary intraepithelial neoplasia BILIN
cervical intraepithelial neoplasia CIN
endometrial intraepithelial neoplasia EIN
gastrointestinal intraepithelial neoplasia[1] GIN
penile intraepithelial neoplasia PEIN
prostatic intraepithelial neoplasia PIN
vaginal intraepithelial neoplasia VAIN
vulvar intraepithelial neoplasia VIN


  1. ^ Schlemper, RJ; et al. (2000). "The Vienna classification of gastrointestinal epithelial neoplasia". Gut. 47 (2): 251–5. doi:10.1136/gut.47.2.251. PMC 1728018. PMID 10896917.