Vaginal intraepithelial neoplasia
|Vaginal intraepithelial neoplasia|
|Classification and external resources|
Like cervical intraepithelial neoplasia, VAIN comes in three stages, VAIN 1, 2, and 3. In VAIN 1, a third of the thickness of the cells in the vaginal skin are abnormal, while in VAIN 3, the full thickness is affected. VAIN 3 is also known as carcinoma in-situ, or stage 0 vaginal cancer.
Infection with certain types of the human papillomavirus ("high-risk types") may be associated with up to 80% of cases of VAIN. Vaccinating girls with HPV vaccine before initial sexual contact has been shown to reduce incidence of VAIN.
One study found that most cases of VAIN were located in the upper third of the vagina, and were multifocal. In the same study, 65 and 10% patients with VAIN also had cervical intraepithelial neoplasia and vulvar intraepithelial neoplasia, respectively.
In another study, most cases of VAIN went into remission after a single treatment, but about 5% of the cases studied progressed into a more serious condition despite treatment.
- Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1192. ISBN 1-4160-2999-0.
- Diakomanolis, E; Stefanidis, K; Rodolakis, A; Haidopoulos, D; Sindos, M; Chatzipappas, I; Michalas, S (2002). "Vaginal intraepithelial neoplasia: report of 102 cases.". European journal of gynaecological oncology. 23 (5): 457–9. PMID 12440826.
- Cancer Research UK (2002). The stages of cancer of the vagina. CancerHelp UK. Retrieved January 3, 2008.
- Cancer Research UK (2002). Risks and causes of vaginal cancer. CancerHelp UK. Retrieved January 3, 2008.
- "FDA Approves Expanded Uses for Gardasil to Include Preventing Certain Vulvar and Vaginal Cancers". 2008-09-12. Retrieved 2010-02-13.
- Dodge, JA; Eltabbakh, GH; Mount, SL; Walker, RP; Morgan, A (2001). "Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia.". Gynecologic Oncology. 83 (2): 363–9. PMID 11606098. doi:10.1006/gyno.2001.6401.
- Sillman, FH; Fruchter, RG; Chen, YS; Camilien, L; Sedlis, A; McTigue, E (1997). "Vaginal intraepithelial neoplasia: risk factors for persistence, recurrence, and invasion and its management.". American Journal of Obstetrics and Gynecology. 176 (1 Pt 1): 93–9. PMID 9024096. doi:10.1016/S0002-9378(97)80018-X.
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