Invasive urothelial carcinoma
 | This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages)
|
![[icon]](/wiki/File:Wiki_letter_w_cropped.svg){kind=small}
| Invasive urothelial carcinoma | |
|---|---|
| Specialty | Oncology |
Invasive urothelial carcinoma is a type of Transitional cell carcinoma (TCC, also urothelial cell carcinoma or UCC) and is a type of cancer that develops in the urinary system: the kidney, urinary bladder, and accessory organs. It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus.
Invasive urothelial carcinoma originates from tissue lining the inner surface of these hollow organs - transitional epithelium.[1] It can extend from the kidney collecting system to the bladder.[2]
Generally speaking, Invasive urotherlial carcinoma is a cancer of the urothelium that develops from epithelial cells lining the lumens of urinary system organs. The term Carcinoma (from the Greek karkinos, or "crab", and -oma, "growth") is a type of cancer [3] A carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that generally arises from cells originating in the endodermal or ectodermal germ layer during embryogenesis.[4] Is a form of cancer of one type of Urothelial lesion and a form of Papillary urothelial lesions. Urothelium (or uroepithelium) is an example of "transitional epithelium". It is the type of epithelium that lines much of the urinary tract including the renal pelvis, the ureters, the bladder, and parts of the urethra.[5][6]
Symptoms
Symptoms vary between individuals and can be dependent upon the stage of growth of the carcinoma. Presence of the carcinoma can lead to be asymptomatic blood in the urine (hematuria) Hematuria can be visible or detected microscopically. Visible hematuria is when urine appears red or brown and can be seen with the naked eye. Other symptoms are not specific. Other inflammatory conditions that affect the bladder and kidney can create similar symptoms. Early detection facilitates curing the disease. Other symptoms can involve:
- pain or burning on urination
- the sensation of not being able to completely empty the bladder
- the sensation of needing to urinate more often or more frequently than normal
These symptoms are general and also indicate less serious problems.[7]
Prognosis
Prognosis is highly variable and dependent upon a multitude of factors. Reoccurrence does occur.[8]
Treatment
Treatment is determined on a case-by-case basis.[9][10]
See also
Transitional epithelium
References
- ^ "transitional cell carcinoma" at Dorland's Medical Dictionary
- ^ Selvaraj V, Govindarajan P, Deepak M, Sivaraj M. "The creeping tumor:" An unusual presentation of upper urinary tract malignancy. Indian J Urol 2014;30:454-5.
- ^ Lemoine, Nigel Kirkham, Nicholas R. (2001). Progress in pathology. London: Greenwich Medical Media. p. 52. ISBN 9781841100500.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ "Definition of Carcinoma". Retrieved 2014-01.
{{cite web}}: Check date values in:|accessdate=(help); Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - ^ Andersson, 2011: p. 134
- ^ Amornpan, Ajjimaporn; Botsford, Tom; Garrett, Scott H; Sens, Mary Ann; Zhou, Xu Dong; Dunlevy, Jane R; Sens, Donald A; Somji, Seema (2012 Jul 4.). "ZIP8 expression in human proximal tubule cells, human urothelial cells transformed by Cd+2 and As+3 and in specimens of normal human urothelium and urothelial cancer". Cancer Cell Int. 12 (16). doi:10.1186/1475-2867-12-16.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: unflagged free DOI (link) - ^ "Bladder Cancer: SYMPTOMS OF BLADDER CANCER". Johns Hopkins University. Retrieved 2015-03-04.
- ^ May M, Brookman-Amissah S, Roigas J, et al. (March 2009). "Prognostic Accuracy of Individual Uropathologists in Noninvasive Urinary Bladder Carcinoma: A Multicentre Study Comparing the 1973 and 2004 World Health Organisation Classifications". Eur. Urol. 57 (5): 850–8. doi:10.1016/j.eururo.2009.03.052. PMID 19346063.
- ^ Babjuk, M.; Oosterlinck, W.; Sylveste, R.; Kaasinen, E.; Böhle, A.; Palou-Redorta, J.; Rouprêt, M. (July–August 201). "EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update". Actas Urológicas Españolas (English Edition). 36 (7): 389–402. doi:10.1016/j.acuroe.2011.12.007.
{{cite journal}}: Check date values in:|date=(help) - ^ "Bladder cancer treatment; invasive cancer". Retrieved 2015-03-04.
Bibliography
- Andersson, Karl-Erik (2011). Urinary Tract. Springer. ISBN 978-3-642-16498-9.
External links
- Urothelium at the U.S. National Library of Medicine Medical Subject Headings (MeSH)