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Junctophilin 3
Symbols JPH3 ; CAGL237; HDL2; JP-3; JP3; TNRC22
External IDs OMIM605268 MGI1891497 HomoloGene10762 GeneCards: JPH3 Gene
RNA expression pattern
PBB GE JPH3 220188 at tn.png
More reference expression data
Species Human Mouse
Entrez 57338 57340
Ensembl ENSG00000154118 ENSMUSG00000025318
UniProt Q8WXH2 Q9ET77
RefSeq (mRNA) NM_001271604 NM_020605
RefSeq (protein) NP_001258533 NP_065630
Location (UCSC) Chr 16:
87.6 – 87.7 Mb
Chr 8:
121.73 – 121.79 Mb
PubMed search [1] [2]

Junctophilin-3 is a protein that in humans is encoded by the JPH3 gene.[1][2][3]

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family.[3]


  1. ^ Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K (Aug 2000). "Junctophilins: a novel family of junctional membrane complex proteins". Mol Cell 6 (1): 11–22. doi:10.1016/S1097-2765(05)00005-5. PMID 10949023. 
  2. ^ Nishi M, Mizushima A, Nakagawara K, Takeshima H (Sep 2000). "Characterization of human junctophilin subtype genes". Biochem Biophys Res Commun 273 (3): 920–7. doi:10.1006/bbrc.2000.3011. PMID 10891348. 
  3. ^ a b "Entrez Gene: JPH3 junctophilin 3". 

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