Tatupu made his debut for the Western Force in 2008 against the Lions in Johannesburg. Tatupu is also a former league player having represented Samoa. After leaving Western Force he joined Otago in the NPC before joining French side Castres. It was announced on 31 March 2011 that Tatupu will join English side Exeter Chiefs.
On 16 May 2013 French Pro D2 side US Carcassonne side announced on their official website that they had signed Tatupu on a two-year deal.