KIF6

KIF6
Identifiers
Aliases	KIF6, C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1, kinesin family member 6
External IDs	OMIM: 613919; MGI: 1098238; HomoloGene: 35308; GeneCards: KIF6; OMA:KIF6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	39,725,408 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	50,216,875 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; corpus callosum; ; sperm; ; bronchial epithelial cell; ; C1 segment; ; oocyte; ; olfactory zone of nasal mucosa; ; testicle; ; substantia nigra; ; internal globus pallidus;
	Top expressed in
	otolith organ; ; utricle; ; lumbar subsegment of spinal cord; ; spermatocyte; ; Rostral migratory stream; ; tail of embryo; ; embryo; ; embryo; ; lateral ventricle; ; choroid plexus of lateral ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; protein binding; ATP binding;
Cellular component	cytoplasm; male germ cell nucleus; microtubule; cytoskeleton; kinesin complex;
Biological process	microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	221458
	319991
	ENSG00000164627
	ENSMUSG00000023999
	Q6ZMV9
	n/a
NM_001289020; NM_001289021; NM_001289024; NM_145027; NM_001351503;
	NM_001351566
	NM_177052
NP_001275949; NP_001275950; NP_001275953; NP_659464; NP_001338432;
	NP_001338495
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene.^[5] This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164627 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023999 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Kinesin family member 6".

Koroleva, O. S.; Pushkov, A. A.; Blagodatskikh, K. A.; Baranova, O. A.; Azizova, O. A.; Nosikov, V. V.; Reznichenko, N. E.; Zateĭshchikov, D. A. (2011). "Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease". Kardiologiia. 51 (9): 4–12. PMID 21943003.
Bare, L. A.; Ruiz-Narvaéz, E. A.; Tong, C. H.; Arellano, A. R.; Rowland, C. M.; Catanese, J. J.; Sacks, F. M.; Devlin, J. J.; Campos, H (2010). "Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: A Costa Rican population". PLoS ONE. 5 (9): e13081. doi:10.1371/journal.pone.0013081. PMC 2947524. PMID 20927332.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Peng, P; Lian, J; Huang, R. S.; Xu, L; Huang, Y; Ba, Y; Yang, X; Huang, X; Dong, C; Zhang, L; Ye, M; Zhou, J; Duan, S (2012). "Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect". PLoS ONE. 7 (12): e50126. doi:10.1371/journal.pone.0050126. PMC 3517591. PMID 23236363.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Akao, H; Polisecki, E; Kajinami, K; Trompet, S; Robertson, M; Ford, I; Jukema, J. W.; De Craen, A. J.; Westendorp, R. G.; Shepherd, J; Packard, C; Buckley, B. M.; Schaefer, E. J. (2012). "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly". Atherosclerosis. 220 (2): 456–62. doi:10.1016/j.atherosclerosis.2011.11.037. PMID 22192511.
Liu, X; Gomez-Pinillos, A; Loder, C; Carrillo-De Santa Pau, E; Qiao, R; Unger, P. D.; Kurek, R; Oddoux, C; Melamed, J; Gallagher, R. E.; Mandeli, J; Ferrari, A. C. (2012). "KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation". The American Journal of Pathology. 181 (3): 1007–16. doi:10.1016/j.ajpath.2012.06.008. PMC 3432435. PMID 22819534.
Davani, S; Gozalo, C; Gambert, S; Chalmers, D; Gambert, P; Schiele, F; Kantelip, J. P.; Meneveau, N (2010). "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction". Atherosclerosis. 210 (1): 48–50. doi:10.1016/j.atherosclerosis.2009.11.041. PMID 20044086.
Hu, M; Lui, S. S.; Mak, V. W.; Chu, T. T.; Lee, V. W.; Poon, E. W.; Tsui, T. K.; Ko, G. T.; Baum, L; Tam, L. S.; Li, E. K.; Tomlinson, B (2010). "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients". Pharmacogenetics and Genomics. 20 (10): 634–7. doi:10.1097/FPC.0b013e32833de489. PMID 20679960.
Koroleva, O. S.; Zateĭshchikov, D. A. (2010). "Motor protein Kinesin-6 and ischemic heart disease". Kardiologiia. 50 (6): 54–62. PMID 20659029.
Bhanushali, A. A.; Contractor, A; Shah, V. T.; Das, B. R. (2011). "Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians". Genetic Testing and Molecular Biomarkers. 15 (12): 883–6. doi:10.1089/gtmb.2011.0079. PMID 21810021.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164627 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Kinesin family member 6".

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References

Further Reading