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Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KIR3DL3 ; CD158Z; KIR2DS2; KIR3DL7; KIR44; KIRC1
External IDs OMIM610095 HomoloGene77448 GeneCards: KIR3DL3 Gene
Species Human Mouse
Entrez 115653 245615
Ensembl ENSG00000242019 ENSMUSG00000057439
UniProt P43631 E9Q1D8
RefSeq (mRNA) NM_153443 NM_177748
RefSeq (protein) NP_703144 NP_808416
Location (UCSC) Chr 19:
54.72 – 54.74 Mb
Chr X:
136.45 – 136.54 Mb
PubMed search [1] [2]

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.[1][2]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.[2]


  1. ^ Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID 11513144. 
  2. ^ a b "Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3". 

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