Kelch-like protein 20

KLHL20
Identifiers
Aliases	KLHL20, KHLHX, KLEIP, KLHLX, kelch like family member 20
External IDs	OMIM: 617679; MGI: 2444855; HomoloGene: 8699; GeneCards: KLHL20; OMA:KLHL20 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,786,692 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,959,081 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; tendon of biceps brachii; ; sperm; ; gonad; ; nipple; ; popliteal artery; ; tibial arteries; ; ventricular zone; ; gallbladder;
	Top expressed in
	facial motor nucleus; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; cumulus cell; ; anterior horn of spinal cord; ; blood; ; genital tubercle; ; granulocyte; ; trigeminal ganglion; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; interferon-gamma binding; actin binding;
Cellular component	nucleus; cell projection; actin cytoskeleton; Cul3-RING ubiquitin ligase complex; perinuclear region of cytoplasm; dendrite; trans-Golgi network; axon; cytoplasm; Golgi apparatus; PML body; cytosol;
Biological process	Golgi to endosome transport; protein K33-linked ubiquitination; cytoskeleton organization; protein transport; proteasome-mediated ubiquitin-dependent protein catabolic process; response to interferon-alpha; protein ubiquitination; negative regulation of apoptotic process; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	27252
	226541
	ENSG00000076321
	ENSMUSG00000026705
	Q9Y2M5
	Q8VCK5
	NM_014458
	NM_001039482; NM_144876
	NP_055273
	NP_001034571
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.^[5]^[6]

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076321 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hara T, Ishida H, Raziuddin R, Dorkhom S, Kamijo K, Miki T (Mar 2004). "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells". Mol Biol Cell. 15 (3): 1172–84. doi:10.1091/mbc.E03-07-0531. PMC 363103. PMID 14668487.
^ ^a ^b "Entrez Gene: KLHL20 kelch-like 20 (Drosophila)".

Adams J, Kelso R, Cooley L (2000). "The kelch repeat superfamily of proteins: propellers of cell function". Trends Cell Biol. 10 (1): 17–24. doi:10.1016/S0962-8924(99)01673-6. PMID 10603472.
Nemes JP, Benzow KA, Moseley ML, et al. (2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum. Mol. Genet. 9 (10): 1543–51. doi:10.1093/hmg/9.10.1543. PMID 10888605.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Nacak TG, Alajati A, Leptien K, et al. (2007). "The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis". Circ. Res. 100 (8): 1155–63. doi:10.1161/01.RES.0000265844.56493.ac. PMID 17395875.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076321 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14668487-5] Hara T, Ishida H, Raziuddin R, Dorkhom S, Kamijo K, Miki T (Mar 2004). "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells". Mol Biol Cell. 15 (3): 1172–84. doi:10.1091/mbc.E03-07-0531. PMC 363103. PMID 14668487.

[entrez-6] "Entrez Gene: KLHL20 kelch-like 20 (Drosophila)".

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References

Further reading