L1TD1

L1TD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LR6, 3SOO
Identifiers
Aliases	L1TD1, ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs	MGI: 3578435; HomoloGene: 136289; GeneCards: L1TD1; OMA:L1TD1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	62,212,328 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	98,626,717 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; placenta; ; appendix; ; mucosa of transverse colon; ; white blood cell; ; monocyte; ; right testis; ; left testis; ; epithelium of colon;
	Top expressed in
	yolk sac; ; epiblast; ; embryo; ; blastocyst; ; blastocyst; ; primitive streak; ; morula; ; embryo; ; tail of embryo; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	single-stranded RNA binding; protein binding;
Cellular component	ribonucleoprotein complex;
Biological process	transposition, RNA-mediated;
	Sources:Amigo / QuickGO
Orthologs
	54596
	381591
	ENSG00000240563
	ENSMUSG00000087166
	Q5T7N2
	Q587J6
	NM_019079; NM_001164835
	NM_001081202
	NP_001158307; NP_061952
	NP_001074671
	Wikidata
View/Edit Human	View/Edit Mouse

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers. ^[5] ^[6] ^[7] ^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000240563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000087166 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
^ Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
^ Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
^ Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996. S2CID 24719399.

References

Further reading