LCP1

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LCP1
Protein LCP1 PDB 2d85.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
External IDs MGI: 104808 HomoloGene: 80174 GeneCards: LCP1
Genetically Related Diseases
fatty liver disease[1]
RNA expression pattern
PBB GE LCP1 208885 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002298

NM_001247984
NM_008879

RefSeq (protein)

NP_002289
NP_002289.2

NP_001234913.1
NP_032905.2
NP_001234913
NP_032905

Location (UCSC) Chr 13: 46.13 – 46.21 Mb Chr 14: 75.13 – 75.23 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[4]

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with LCP1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (Jun 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166. 
  5. ^ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)". 

Further reading[edit]