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Lymphocyte cytosolic protein 1 (L-plastin)
Protein LCP1 PDB 2d85.png
PDB rendering based on 2d85.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LCP1 ; CP64; HEL-S-37; L-PLASTIN; LC64P; LPL; PLS2
External IDs OMIM153430 MGI104808 HomoloGene80174 GeneCards: LCP1 Gene
RNA expression pattern
PBB GE LCP1 208885 at tn.png
More reference expression data
Species Human Mouse
Entrez 3936 18826
Ensembl ENSG00000136167 ENSMUSG00000021998
UniProt P13796 Q61233
RefSeq (mRNA) NM_002298 NM_001247984
RefSeq (protein) NP_002289 NP_001234913
Location (UCSC) Chr 13:
46.13 – 46.21 Mb
Chr 14:
75.13 – 75.23 Mb
PubMed search [1] [2]

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.[1]

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.[2]


  1. ^ Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (Jun 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry 29 (4): 1055–62. doi:10.1021/bi00456a030. PMID 2111166. 
  2. ^ "Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)". 

Further reading[edit]