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LIM2

From Wikipedia, the free encyclopedia
LIM2
Identifiers
AliasesLIM2, CTRCT19, MP17, MP19, lens intrinsic membrane protein 2
External IDsOMIM: 154045; MGI: 104698; HomoloGene: 12744; GeneCards: LIM2; OMA:LIM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030657
NM_001161748

NM_177693

RefSeq (protein)

NP_001155220
NP_085915

NP_808361

Location (UCSC)Chr 19: 51.38 – 51.39 MbChr 7: 43.08 – 43.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.[5][6]

The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1; MIM 123660). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD.

This protein appears to contain 4 transmembrane domains, is a substrate for cAMP-dependent protein kinase and protein kinase C, and binds with calmodulin. Taken together, these suggest that MP19 functions in some way as a junctional component, possibly involved with lens cell communication. It has been shown to be involved with cataractogenesis.[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105370Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000118560Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Church RL, Wang J (Jul 1992). "Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19". Curr Eye Res. 11 (5): 421–4. doi:10.3109/02713689209001795. PMID 1606837.
  6. ^ a b "Entrez Gene: LIM2 lens intrinsic membrane protein 2, 19kDa".

Further reading

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