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Aliases LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E
External IDs MGI: 106651 HomoloGene: 56411 GeneCards: LY6E
RNA expression pattern
PBB GE LY6E 202145 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 8: 143.02 – 143.02 Mb Chr 15: 74.96 – 74.96 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.[3][4][5] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.[6] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.[7] Further research is required to validate Ly6E for translation research. [1]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Capone MC, Gorman DM, Ching EP, Zlotnik A (Sep 1996). "Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family". J Immunol. 157 (3): 969–73. PMID 8757598. 
  4. ^ Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z (Jul 1996). "RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell". Proc Natl Acad Sci U S A. 93 (12): 5910–4. doi:10.1073/pnas.93.12.5910. PMC 39161Freely accessible. PMID 8650192. 
  5. ^ "Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E". 
  6. ^ Luo, Linlin; McGarvey, Peter; Madhavan, Subha; Kumar, Rakesh; Gusev, Yuriy; Upadhyay, Geeta (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome". Oncotarget. 7: 11165–93. doi:10.18632/oncotarget.7163. ISSN 1949-2553. PMC 4905465Freely accessible. PMID 26862846. 
  7. ^ Hossiny, Midrar A.; Luo, Linlin; Frazier, William R.; Steiner, Noriko; Gusev, Yuriy; Kallakury, Bhaskar; Glasgow, Eric; Creswell, Karen; Madhavan, Subha; Kumar, Rakesh; Upadhyay, Geeta (2016-04-11). "Ly6E/K signaling to TGF-ß promotes breast cancer progression, immune escape and drug resistance". Cancer Research. 76: canres.2654.2015. doi:10.1158/0008-5472.CAN-15-2654. ISSN 0008-5472. 

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