LYAR

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LYAR
Protein LYAR PDB 1wjv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LYAR, ZC2HC2, ZLy1 antibody reactive
External IDs MGI: 107470 HomoloGene: 41200 GeneCards: LYAR
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LYAR
Genomic location for LYAR
Band 4p16.3 Start 4,267,701 bp[1]
End 4,290,169 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145725
NM_017816

NM_025281

RefSeq (protein)

NP_001139197
NP_060286

NP_079557

Location (UCSC) Chr 4: 4.27 – 4.29 Mb Chr 5: 38.22 – 38.23 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene (Ly-1 antibody reactive clone).[5]

LYAR contains a zinc finger motif and three copies of nuclear localization signals. LYAR is mainly localized to the nucleoli. LYAR is present at high levels in early embryos and preferentially in the liver fetal thymus.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145220 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067367 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: LYAR hypothetical protein FLJ20425". 
  6. ^ Su L, Hershberger RJ, Weissman IL (May 1993). "LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation". Genes Dev. 7 (5): 735–48. doi:10.1101/gad.7.5.735. PMID 8491376. 

Further reading[edit]