Leukotriene-C4 synthase

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leukotriene-C4 synthase
3leo.jpg
Leukotriene C4 synthase dodekamer, Human
Identifiers
EC number 4.4.1.20
CAS number 90698-32-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a leukotriene-C4 synthase (EC 4.4.1.20) is an enzyme that catalyzes the chemical reaction

leukotriene C4 leukotriene A4 + glutathione

Hence, this enzyme has one substrate, leukotriene C4, and two products, leukotriene A4 and glutathione.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-, tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-, and 7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2PNO, 2UUH, and 2UUI.

References[edit]

  • Bach MK, Brashler JR, Morton DR Jr (1984). "Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase". Arch. Biochem. Biophys. 230 (2): 455–65. PMID 6324687. doi:10.1016/0003-9861(84)90426-0. 
  • Shimizu T (1988). "Enzymes functional in the syntheses of leukotrienes and related compounds". Int. J. Biochem. 20 (7): 661–6. PMID 2846379. doi:10.1016/0020-711X(88)90160-7. 
  • Lam BK, Austen KF (2002). "Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes". Prostaglandins. Other. Lipid. Mediat. 68-69: 511–20. PMID 12432940. doi:10.1016/S0090-6980(02)00052-7. 
  • Christmas P, Weber BM, McKee M, Brown D, Soberman RJ (2002). "Membrane localization and topology of leukotriene C4 synthase". J. Biol. Chem. 277 (32): 28902–8. PMID 12023288. doi:10.1074/jbc.M203074200.