M2M may refer to:
- Mission to Mars (attraction) at Walt Disney World's Magic Kingdom, Florida USA
- Mission to Mars (2000), a science fiction film inspired by the attraction
- M2M (Eclipse), an implementation of the Object Management Group's QVT standard for model transformation
- Machine to machine, direct communication between devices
- Many-to-many (data model), as an entity-relationship model
- Mobile-to-mobile convergence
- Mobile-to-mobile, a classification of phone call on some mobile phone plans
- Man-to-man defense, a defensive tactic used in a variety of sports
- mothers2mothers, an international nonprofit organization dedicated to preventing mother-to-child transmission of HIV
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