MADD (gene)

MADD
Identifiers
Aliases	MADD, DENN, IG20, RAB3GEP, MAP kinase activating death domain
External IDs	OMIM: 603584; MGI: 2444672; HomoloGene: 14249; GeneCards: MADD; OMA:MADD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,330,031 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,183,837 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; apex of heart; ; cingulate gyrus; ; left testis; ; anterior cingulate cortex; ; right testis;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; supraoptic nucleus; ; nucleus of stria terminalis; ; Region I of hippocampus proper; ; lobe of cerebellum; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death receptor binding; guanyl-nucleotide exchange factor activity; protein kinase activator activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cytoplasm; cytosol;
Biological process	regulation of apoptotic process; regulation of extrinsic apoptotic signaling pathway; execution phase of apoptosis; regulation of tumor necrosis factor-mediated signaling pathway; regulation of Rab protein signal transduction; regulation of cell cycle; cell surface receptor signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8567
	228355
	ENSG00000110514
	ENSMUSG00000040687
	Q8WXG6
	Q80U28
NM_001135943; NM_001135944; NM_003682; NM_130470; NM_130471;
	NM_130472; NM_130473; NM_130474; NM_130475; NM_130476
NM_001177719; NM_001177720; NM_001177721; NM_001177722; NM_001177723;
	NM_001177724; NM_001177725; NM_001177726; NM_001177727; NM_001177728; NM_001177729; NM_145527
NP_001129415; NP_001129416; NP_003673; NP_569826; NP_569827;
	NP_569828; NP_569829; NP_569830; NP_569831; NP_569832; NP_001363500; NP_001363501; NP_001363502; NP_001363503; NP_001363504; NP_001363505; NP_001363506; NP_001363507; NP_001363508; NP_001363509; NP_001363510; NP_001363511; NP_001363512; NP_001363513; NP_001363514; NP_001363515; NP_001363522; NP_001363523; NP_001363524; NP_001363525; NP_001363526; NP_001363527; NP_001363528; NP_001363529; NP_001363530; NP_001363531; NP_001363532; NP_001363533; NP_001363534; NP_001363535; NP_001363536; NP_001363537; NP_001363538; NP_001363539; NP_001363540; NP_001363541; NP_001363542; NP_001363543; NP_001363544; NP_001363545; NP_001363546; NP_001363547; NP_001363548; NP_001363549; NP_001363550; NP_001363551; NP_001363552; NP_001363553; NP_001363554; NP_001363555; NP_001363556; NP_001363557; NP_001363558; NP_001363559; NP_001363560; NP_001363561; NP_001363562; NP_001363563; NP_001363564; NP_001363565; NP_001363566; NP_001363567; NP_001363568; NP_001363569; NP_001363570; NP_001363571; NP_001363572; NP_001363573; NP_001363574; NP_001363575; NP_001363576; NP_001363577; NP_001363578; NP_001363579; NP_001363580; NP_001363581; NP_001363582; NP_001363583; NP_001363584; NP_001363585; NP_001363586; NP_001363587; NP_001363588; NP_001363589; NP_001363590; NP_001363591; NP_001363592
	NP_001171190; NP_001171191; NP_663502
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110514 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040687 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem. 272 (18): 12069–75. doi:10.1074/jbc.272.18.12069. PMID 9115275.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. doi:10.1139/gen-41-4-543. PMID 9796103.
^ "Entrez Gene: MADD MAP-kinase activating death domain".

References

Further reading