MAGI3

MAGI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SOE
Identifiers
Aliases	MAGI3, MAGI-3, dJ730K3.2, membrane associated guanylate kinase, WW and PDZ domain containing 3
External IDs	OMIM: 615943; MGI: 1923484; HomoloGene: 26431; GeneCards: MAGI3; OMA:MAGI3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	113,685,923 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	104,127,690 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; nasal epithelium; ; mucosa of ileum; ; jejunal mucosa; ; mucosa of colon; ; palpebral conjunctiva; ; mucosa of sigmoid colon; ; corpus epididymis; ; pars compacta; ; mucosa of pharynx;
	Top expressed in
	atrioventricular valve; ; globus pallidus; ; habenula; ; superior colliculus; ; dorsal tegmental nucleus; ; left lung lobe; ; medial vestibular nucleus; ; ventral tegmental area; ; ciliary body; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular adaptor activity; nucleotide binding; guanylate kinase activity; protein binding; ATP binding;
Cellular component	plasma membrane; membrane; nucleus; cell-cell junction; bicellular tight junction; cell junction; cytoplasm;
Biological process	regulation of JNK cascade; intracellular signal transduction; viral process; signal transduction; apoptotic process; GDP metabolic process; GMP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	260425
	99470
	ENSG00000081026
	ENSMUSG00000052539
	Q5TCQ9
	Q9EQJ9
	NM_001142782; NM_020965; NM_152900
	NM_001159354; NM_133853
	NP_001136254; NP_690864; NP_690864.2
	NP_001152826; NP_598614
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

MAGI3 has been shown to interact with PTPRB^[8] and PTEN.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081026 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052539 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
^ ^a ^b Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Aug 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J Biol Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3".
^ Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell. Sci. 116 (Pt 7). England: 1279–89. doi:10.1242/jcs.00302. ISSN 0021-9533. PMID 12615970. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading