MAN2B2

MAN2B2
Identifiers
Aliases	MAN2B2, mannosidase alpha class 2B member 2, EpMAN
External IDs	MGI: 1195262; HomoloGene: 7411; GeneCards: MAN2B2; OMA:MAN2B2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	6,623,362 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	36,987,997 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; stromal cell of endometrium; ; Descending thoracic aorta; ; right coronary artery; ; ascending aorta; ; decidua; ; parotid gland; ; synovial joint; ; popliteal artery; ; tibial arteries;
	Top expressed in
	spermatocyte; ; spermatid; ; granulocyte; ; epithelium of small intestine; ; yolk sac; ; stroma of bone marrow; ; seminiferous tubule; ; tail of embryo; ; ileum; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	catalytic activity; hydrolase activity; alpha-mannosidase activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; carbohydrate binding; mannan endo-1,6-alpha-mannosidase activity;
Cellular component	extracellular region; extracellular exosome; lysosomal lumen; extracellular space; vacuolar membrane;
Biological process	metabolism; mannose metabolic process; protein deglycosylation; oligosaccharide catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23324
	17160
	ENSG00000013288
	ENSMUSG00000029119
	Q9Y2E5
	O54782
	NM_001292038; NM_015274
	NM_008550
	NP_001278967; NP_056089
	NP_032576
	Wikidata
View/Edit Human	View/Edit Mouse

Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene.^[5]^[6]^[7]

Epididymis-specific alpha-mannosidase precursor

Mannosidase alpha class 2B member

core-specific lysosomal alpha-1,6-Mannosidase

epididymis-specific alpha-mannosidase

mannosidase, alpha, class 2B, member

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013288 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ Park C, Meng L, Stanton LH, Collins RE, Mast SW, Yi X, Strachan H, Moremen KW (Oct 2005). "Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism". J Biol Chem. 280 (44): 37204–16. doi:10.1074/jbc.M508930200. PMC 1351102. PMID 16115860. {{cite journal}}: Cite has empty unknown parameter: |month= (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
^ "Entrez Gene: MAN2B2 mannosidase, alpha, class 2B, member 2".