MAPK8IP1

MAPK8IP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Identifiers
Aliases	MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
External IDs	OMIM: 604641 MGI: 1309464 HomoloGene: 31314 GeneCards: MAPK8IP1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,906,465 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,231,608 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; tibial nerve; ; prefrontal cortex; ; Brodmann area 9; ; Brodmann area 10; ; amygdala; ; middle frontal gyrus; ; ganglionic eminence; ; sural nerve; ; nucleus accumbens;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; cerebellar cortex; ; superior surface of tongue; ; gallbladder; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus; ; primary motor cortex; ; lateral geniculate nucleus; ; lateral hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	MAP-kinase scaffold activity; protein kinase inhibitor activity; protein binding; kinesin binding; protein kinase binding; JUN kinase binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding;
Cellular component	cytoplasm; cell body; cytosol; dendritic growth cone; endoplasmic reticulum membrane; mitochondrial membranes; membrane; dentate gyrus mossy fiber; axonal growth cone; synapse; axon; dendrite; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; neuron projection; nucleus; plasma membrane;
Biological process	regulation of transcription, DNA-templated; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of JNK cascade; regulation of JNK cascade; JUN phosphorylation; negative regulation of JUN kinase activity; vesicle-mediated transport; signal transduction; positive regulation of MAPK cascade; positive regulation of JNK cascade; regulation of CD8-positive, alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9479
	19099
	ENSG00000121653
	ENSMUSG00000027223
	Q9UQF2
	Q9WVI9
	NM_005456
	NM_001202445; NM_001202446; NM_011162
	NP_005447
	NP_001189374; NP_001189375; NP_035292
	Wikidata
View/Edit Human	View/Edit Mouse

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.^[5]^[6]

Template:PBB Summary

Interactions

MAPK8IP1 has been shown to interact with MAP3K10,^[7] DUSP16,^[8] Mitogen-activated protein kinase 9,^[7]^[9] MAPK8,^[9]^[10] LRP2,^[11]^[12] LRP1,^[11] MAP3K12,^[7] MAP2K7,^[7] MAPK8IP2^[7] and MAP3K11.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121653 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ (August 1997). "A cytoplasmic inhibitor of the JNK signal transduction pathway". Science. 277 (5326): 693–6. doi:10.1126/science.277.5326.693. PMID 9235893.
^ Bonny C, Nicod P, Waeber G (March 1998). "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells". J Biol Chem. 273 (4): 1843–6. doi:10.1074/jbc.273.4.1843. PMID 9442013.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b ^c ^d ^e ^f Yasuda, J; Whitmarsh A J; Cavanagh J; Sharma M; Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10). UNITED STATES: 7245–54. doi:10.1128/mcb.19.10.7245. ISSN 0270-7306. PMC 84717. PMID 10490659.
^ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (March 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12). United States: 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Whitmarsh, A J; Cavanagh J; Tournier C; Yasuda J; Davis R J (September 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383). UNITED STATES: 1671–4. doi:10.1126/science.281.5383.1671. ISSN 0036-8075. PMID 9733513.
^ Cai, Yi; Lechner Mark S; Nihalani Deepak; Prindle Marc J; Holzman Lawrence B; Dressler Gregory R (January 2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation". J. Biol. Chem. 277 (2). United States: 1217–22. doi:10.1074/jbc.M109663200. ISSN 0021-9258. PMID 11700324.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33). UNITED STATES: 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Petersen, Helle Heibroch; Hilpert Jan; Militz Daniel; Zandler Valerie; Jacobsen Christian; Roebroek Anton J M; Willnow Thomas E (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3). England: 453–61. doi:10.1242/jcs.00243. ISSN 0021-9533. PMID 12508107.

Interactions

References

Further reading