MARCKSL1

MARCKSL1
Identifiers
Aliases	MARCKSL1, F52, MACMARCKS, MLP, MLP1, MRP, MARCKS-like 1, MARCKS like 1
External IDs	OMIM: 602940; MGI: 97143; HomoloGene: 40748; GeneCards: MARCKSL1; OMA:MARCKSL1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,336,233 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,409,778 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; ganglionic eminence; ; spinal cord; ; C1 segment; ; superior vestibular nucleus; ; middle frontal gyrus; ; subthalamic nucleus; ; pons; ; ventricular zone; ; ventral tegmental area;
	Top expressed in
	neural tube; ; maxillary prominence; ; medial ganglionic eminence; ; mandibular prominence; ; somite; ; abdominal wall; ; ventricular zone; ; primitive streak; ; transitional epithelium of urinary bladder; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; calmodulin binding;
Cellular component	cytoplasm; plasma membrane; extracellular exosome; membrane; cytoskeleton;
Biological process	positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	65108
	17357
	ENSG00000175130
	ENSMUSG00000047945
	P49006
	P28667
	NM_023009
	NM_010807
	NP_075385
	NP_034937
	Wikidata
View/Edit Human	View/Edit Mouse

MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.^[5]^[6]

Function

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants.^[6]

Interactions

MARCKSL1 has been shown to interact with DCTN2^[7] and JNK.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175130 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047945 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ (August 1998). "Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects". Genomics. 49 (2): 253–64. doi:10.1006/geno.1998.5247. PMID 9598313.
^ ^a ^b "Entrez Gene: MARCKSL1 MARCKS-like 1".
^ Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET (September 2012). "c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells". Mol Cell Biol. 32 (17): 3513–26. doi:10.1128/MCB.00713-12. PMC 3421996. PMID 22751924.

Umekage T, Kato K (1991). "A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS". FEBS Lett. 286 (1–2): 147–51. doi:10.1016/0014-5793(91)80961-2. PMID 1864362.
Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ (1994). "Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein". J. Biol. Chem. 269 (12): 9361–7. PMID 8132675.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Yue L, Lu S, Garces J, Jin T, Li J (2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Hsia TC, Lin CC, Wang JJ, Ho ST, Kao A (2002). "Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression". Lung. 180 (3): 173–9. doi:10.1007/s004080000091. PMID 12177731.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175130 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047945 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9598313-5] Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ (August 1998). "Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects". Genomics. 49 (2): 253–64. doi:10.1006/geno.1998.5247. PMID 9598313.

[entrez-6] "Entrez Gene: MARCKSL1 MARCKS-like 1".

[pmid10827182-7] Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid22751924-8] Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET (September 2012). "c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells". Mol Cell Biol. 32 (17): 3513–26. doi:10.1128/MCB.00713-12. PMC 3421996. PMID 22751924.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

Function

Interactions

References

Further reading