MC2 may refer to:
- Maison de la Culture de Grenoble, a venue for performances in Grenoble, France
- Marvel Comics 2 is an imprint from Marvel Comics whose comic books depict an alternative future timeline for the Marvel Universe
- E = mc² is the equation for mass-energy equivalence
- MC2 France, a French software company
- MC2, an alternate symbol for ACTH receptor
- Midnight Club 2 a street racing game released in 2003.
- Project Mc2
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