MCC (gene)

MCC
Identifiers
Aliases	MCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDs	OMIM: 159350; MGI: 96930; HomoloGene: 20539; GeneCards: MCC; OMA:MCC - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,488,823 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,945,249 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; sural nerve; ; skin of hip; ; left ovary; ; germinal epithelium; ; skin of thigh; ; retinal pigment epithelium; ; endothelial cell; ; seminal vesicula; ; pars reticulata;
	Top expressed in
	zygote; ; otolith organ; ; utricle; ; lobe of cerebellum; ; cerebellar vermis; ; secondary oocyte; ; gastrula; ; ventral tegmental area; ; iris; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor activity;
Cellular component	cytoplasm; plasma membrane; cell projection; membrane; nucleus; lamellipodium; nucleoplasm; cytosol;
Biological process	establishment of protein localization; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell migration; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4163
	328949
	ENSG00000171444
	ENSMUSG00000071856
	P23508
	n/a
	NM_001085377; NM_002387
	NM_001033406; NM_001085373; NM_001085374
	NP_001078846; NP_002378
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171444 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).