Jump to content

MED14

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Dcirovic (talk | contribs) at 23:10, 2 June 2016 (clean up using AWB). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

MED14
Identifiers
AliasesMED14, CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170, mediator complex subunit 14
External IDsOMIM: 300182; MGI: 1349442; HomoloGene: 22082; GeneCards: MED14; OMA:MED14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9282

26896

Ensembl

ENSG00000180182

ENSMUSG00000064127

UniProt

O60244

A2ABV5

RefSeq (mRNA)

NM_004229

NM_001048208
NM_012005

RefSeq (protein)

NP_004220

NP_001041673
NP_036135

Location (UCSC)Chr X: 40.65 – 40.74 MbChr X: 12.54 – 12.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.[5][6][7]

Template:PBB Summary

Interactions

MED14 has been shown to interact with PPARGC1A,[8] Estrogen receptor alpha,[9] STAT2,[10] Cyclin-dependent kinase 8,[11][12] Glucocorticoid receptor[13] and Hepatocyte nuclear factor 4 alpha.[14][15]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180182 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064127 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
  6. ^ Yoshikawa H, Fujiyama A, Nakai K, Inazawa J, Matsubara K (Aug 1998). "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method". Genomics. 49 (2): 237–46. doi:10.1006/geno.1998.5246. PMID 9598311.
  7. ^ "Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa".
  8. ^ Wallberg, Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G (Nov 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5). United States: 1137–49. doi:10.1016/S1097-2765(03)00391-5. ISSN 1097-2765. PMID 14636573. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  9. ^ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5). United States: 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  10. ^ Lau, Joe F; Nusinzon Inna; Burakov Darya; Freedman Leonard P; Horvath Curt M (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Mol. Cell. Biol. 23 (2). United States: 620–8. doi:10.1128/MCB.23.2.620-628.2003. ISSN 0270-7306. PMC 151539. PMID 12509459. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  11. ^ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14). United States: 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  12. ^ Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3). UNITED STATES: 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  13. ^ Hittelman, A B; Burakov D; Iñiguez-Lluhí J A; Freedman L P; Garabedian M J (Oct 1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins". EMBO J. 18 (19). ENGLAND: 5380–8. doi:10.1093/emboj/18.19.5380. ISSN 0261-4189. PMC 1171607. PMID 10508170. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  14. ^ Maeda, Yutaka; Rachez Christophe; Hawel Leo; Byus Craig V; Freedman Leonard P; Sladek Frances M (Jul 2002). "Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205". Mol. Endocrinol. 16 (7). United States: 1502–10. doi:10.1210/mend.16.7.0883. ISSN 0888-8809. PMID 12089346. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  15. ^ Malik, Sohail; Wallberg Annika E; Kang Yun Kyoung; Roeder Robert G (Aug 2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". Mol. Cell. Biol. 22 (15). United States: 5626–37. doi:10.1128/MCB.22.15.5626-5637.2002. ISSN 0270-7306. PMC 133960. PMID 12101254. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Further reading

Template:PBB Further reading

Template:PBB Controls

Retrieved from "https://en.wikipedia.org/w/index.php?title=MED14&oldid=723419331"