MED16

MED16
Identifiers
Aliases	MED16, DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDs	OMIM: 604062; MGI: 2158394; HomoloGene: 64602; GeneCards: MED16; OMA:MED16 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	893,218 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,744,757 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; right lobe of liver; ; gastric mucosa; ; canal of the cervix; ; apex of heart; ; gonad; ; granulocyte; ; anterior pituitary; ; muscle of thigh;
	Top expressed in
	seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; spermatocyte; ; Rostral migratory stream; ; epithelium of stomach; ; dentate gyrus of hippocampal formation granule cell; ; tibiofemoral joint; ; molar; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	vitamin D receptor binding; transcription coregulator activity; thyroid hormone receptor binding; catalytic activity; transcription coactivator activity; protein binding; signaling receptor activity;
Cellular component	nucleoplasm; nucleus; mediator complex; membrane;
Biological process	transcription, DNA-templated; regulation of transcription by RNA polymerase II; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; positive regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10025
	216154
	ENSG00000282092; ENSG00000175221
	ENSMUSG00000013833
	Q9Y2X0
	Q6PGF3
	NM_005481
	NM_001163276; NM_198107; NM_001359629
	NP_005472
	XP_006513550.1; XP_006513551.1
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.^[5]^[6]^[7]

Interactions

MED16 has been shown to interact with Thyroid hormone receptor alpha,^[6] Estrogen receptor alpha^[8] and Cyclin-dependent kinase 8.^[6]^[8]

References

^ ^a ^b ^c ENSG00000175221 GRCh38: Ensembl release 89: ENSG00000282092, ENSG00000175221 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013833 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
^ ^a ^b ^c Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
^ "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".
^ ^a ^b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5). United States: 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.

External links

MED16 human gene location in the UCSC Genome Browser.
MED16 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000175221 GRCh38: Ensembl release 89: ENSG00000282092, ENSG00000175221 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013833 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10235266-5] Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.

[pmid10198638-6] Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

[entrez-7] "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".

[pmid11867769-8] Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5). United States: 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.

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Interactions

References

Further reading

External links