MEP1B

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MEP1B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MEP1B
External IDs MGI: 96964 HomoloGene: 48382 GeneCards: MEP1B
RNA expression pattern
PBB GE MEP1B 207251 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308171
NM_005925

NM_008586

RefSeq (protein)

NP_001295100
NP_005916

NP_032612.2
NP_032612

Location (UCSC) Chr 18: 32.19 – 32.22 Mb Chr 18: 21.07 – 21.1 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.[3][4]

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A; MIM 600388) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. See MIM 600388 for further information on meprins.[supplied by OMIM][4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bond JS, Rojas K, Overhauser J, Zoghbi HY, Jiang W (Jul 1995). "The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively". Genomics. 25 (1): 300–3. doi:10.1016/0888-7543(95)80142-9. PMID 7774936. 
  4. ^ a b "Entrez Gene: MEP1B meprin A, beta". 

Further reading[edit]