MGST3

MGST3
Identifiers
Aliases	MGST3, GST-III, microsomal glutathione S-transferase 3
External IDs	OMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,661,796 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,221,410 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; jejunal mucosa; ; Skeletal muscle tissue of rectus abdominis; ; pons; ; right ventricle; ; thoracic diaphragm; ; apex of heart; ; duodenum; ; Skeletal muscle tissue of biceps brachii; ; mucosa of sigmoid colon;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; olfactory epithelium; ; digastric muscle; ; temporal muscle; ; right ventricle; ; interventricular septum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; glutathione transferase activity; leukotriene-C4 synthase activity; glutathione peroxidase activity; oxidoreductase activity; lyase activity;
Cellular component	integral component of membrane; organelle membrane; extracellular exosome; endoplasmic reticulum membrane; nuclear envelope; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; glutathione derivative biosynthetic process; response to organonitrogen compound; cellular oxidant detoxification; lipid metabolism; leukotriene biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4259
	66447
	ENSG00000143198
	ENSMUSG00000026688
	O14880
	Q9CPU4
	NM_004528
	NM_025569; NM_029392
	NP_004519
	NP_079845
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.^[5]^[6]

Template:PBB Summary

Model organisms

*Mgst3* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal^[7]
Citrobacter infection	Normal^[8]
All tests and analysis from^[9]^[10]

Model organisms have been used in the study of MGST3 function. A conditional knockout mouse line, called Mgst3^{tm1a(KOMP)Wtsi}^[11]^[12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[13]^[14]^[15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[9]^[16] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143198 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: MGST3 microsomal glutathione S-transferase 3".
^ "Salmonella infection data for Mgst3". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Mgst3". Wellcome Trust Sanger Institute.
^ ^a ^b ^c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Model organisms

References

Further reading