MID2

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MID2
Protein MID2 PDB 2dja.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MID2, FXY2, MRX101, RNF60, TRIM1, midline 2
External IDs MGI: 1344333 HomoloGene: 8028 GeneCards: MID2
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for MID2
Genomic location for MID2
Band Xq22.3 Start 107,825,755 bp[1]
End 107,927,193 bp[1]
RNA expression pattern
PBB GE MID2 208384 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012216
NM_052817

NM_011845
NM_001358366
NM_001358367

RefSeq (protein)

NP_036348
NP_438112

NP_035975
NP_001345295
NP_001345296

Location (UCSC) Chr X: 107.83 – 107.93 Mb Chr X: 140.66 – 140.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Midline-2 is a protein that in humans is encoded by the MID2 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[6]

Interactions[edit]

MID2 has been shown to interact with MID1.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080561 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000266 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Buchner G, Montini E, Andolfi G, Quaderi N, Cainarca S, Messali S, Bassi MT, Ballabio A, Meroni G, Franco B (Sep 1999). "MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development". Hum Mol Genet. 8 (8): 1397–407. doi:10.1093/hmg/8.8.1397. PMID 10400986. 
  6. ^ a b "Entrez Gene: MID2 midline 2". 
  7. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245Freely accessible. PMID 11331580. 
  8. ^ Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biol. 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779Freely accessible. PMID 11806752. 

Further reading[edit]