MLF1

MLF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UAL, 3UBW
Identifiers
Aliases	MLF1, myeloid leukemia factor 1
External IDs	OMIM: 601402; MGI: 1341819; HomoloGene: 7839; GeneCards: MLF1; OMA:MLF1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,607,252 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	67,307,336 bp
RNA expression pattern
	Top expressed in
	left testis; ; sperm; ; right testis; ; bronchial epithelial cell; ; myocardium; ; cardiac muscle tissue of right atrium; ; right ventricle; ; right auricle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	spermatid; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; seminiferous tubule; ; spermatocyte; ; digastric muscle; ; intercostal muscle; ; masseter muscle; ; quadriceps femoris muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein domain specific binding; DNA binding;
Cellular component	nucleus; cytoplasm; cytoskeleton; cilium; ciliary basal body; cell projection;
Biological process	multicellular organism development; cell cycle; cell differentiation; myeloid progenitor cell differentiation; transcription, DNA-templated; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4291
	17349
	ENSG00000178053
	ENSMUSG00000048416
	P58340
	Q9QWV4
NM_001130156; NM_001130157; NM_001195432; NM_001195433; NM_001195434;
	NM_022443; NM_001369781; NM_001369782; NM_001369783; NM_001369784; NM_001369785
	NM_001039543; NM_010801
NP_001123628; NP_001123629; NP_001182361; NP_001182362; NP_001182363;
	NP_071888; NP_001356710; NP_001356711; NP_001356712; NP_001356713; NP_001356714; NP_001365774; NP_001365775; NP_001365776; NP_001365777; NP_001365779; NP_001365780; NP_001365781; NP_001365782; NP_001365784
	NP_001034632; NP_034931
	Wikidata
View/Edit Human	View/Edit Mouse

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178053 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID 8570204.
^ "Entrez Gene: MLF1 myeloid leukemia factor 1".

Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1" (PDF). J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995. S2CID 40077371.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Arber DA, Chang KL, Lyda MH, et al. (2003). "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia". Hum. Pathol. 34 (8): 809–13. doi:10.1016/S0046-8177(03)00251-X. PMID 14506644.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hanissian SH, Akbar U, Teng B, et al. (2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoneda-Kato N, Tomoda K, Umehara M, et al. (2005). "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3". EMBO J. 24 (9): 1739–49. doi:10.1038/sj.emboj.7600656. PMC 1142586. PMID 15861129.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yoneda-Kato N, Kato JY (2008). "Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06. PMC 2223285. PMID 17967869.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178053 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8570204-5] Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID 8570204.

[entrez-6] "Entrez Gene: MLF1 myeloid leukemia factor 1".

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References

Further reading