MRPS11

MRPS11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS11, HCC-2, MRP-S11, S11mt, mitochondrial ribosomal protein S11
External IDs	OMIM: 611977; MGI: 1915244; HomoloGene: 32554; GeneCards: MRPS11; OMA:MRPS11 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.3 Start 88,467,453 bp End 88,480,776 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D2 Start 78,432,867 bp End 78,442,737 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon left ventricle left adrenal gland right adrenal gland right adrenal cortex left adrenal cortex right lobe of thyroid gland right auricle muscle of thigh Top expressed in spermatid blastocyst embryo spermatocyte embryo right kidney morula adrenal gland sternocleidomastoid muscle yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome mRNA 5'-UTR binding small ribosomal subunit rRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64963 67994 Ensembl ENSG00000181991 ENSMUSG00000030611 UniProt P82912 Q9DCA2 RefSeq (mRNA) NM_022839 NM_176805 NM_001321970 NM_001321972 NM_001321973 NM_001321974 NM_001321976 NM_026498 NM_001360702 RefSeq (protein) NP_001308899 NP_001308901 NP_001308902 NP_001308903 NP_001308905 NP_073750 NP_789775 n/a Location (UCSC) Chr 15: 88.47 – 88.48 Mb Chr 7: 78.43 – 78.44 Mb PubMed search
Wikidata
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28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ishiguchi H, Izumi H, Torigoe T, et al. (2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6): 900–9. doi:10.1002/ijc.20358. PMID 15300802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.