MSC (gene)

MSC
Identifiers
Aliases	MSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDs	OMIM: 603628; MGI: 1333884; HomoloGene: 3738; GeneCards: MSC; OMA:MSC - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	71,844,412 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	14,826,216 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; left coronary artery; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; testicle; ; stromal cell of endometrium; ; gallbladder; ; apex of heart; ; tibial arteries;
	Top expressed in
	mesenteric lymph nodes; ; morula; ; blastocyst; ; internal carotid artery; ; embryo; ; embryo; ; thymus; ; optic nerve; ; Gonadal ridge; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	roof of mouth development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; branchiomeric skeletal muscle development; transcription, DNA-templated; diaphragm development; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	9242
	17681
	ENSG00000178860
	ENSMUSG00000025930
	O60682
	O88940
	NM_005098
	NM_010827; NM_001360810
	NP_005089
	NP_034957; NP_001347739
	Wikidata
View/Edit Human	View/Edit Mouse

Musculin is a protein that in humans is encoded by the MSC gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025930 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C (Jun 1998). "Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes". Mol Cell Biol. 18 (6): 3130–9. PMC 108895. PMID 9584154.
^ Robb L, Brodnicki T, Copeland NG, Gilbert DJ, Jenkins NA, Harvey RP (May 1999). "Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1". Genomics. 57 (2): 318–9. doi:10.1006/geno.1999.5764. PMID 10198176.
^ "Entrez Gene: MSC musculin (activated B-cell factor-1)".

References

Further reading